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400-1016-218
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- 手機(jī)：400-1016-218
- Q Q：355185756
- 郵箱：355185756@qq.com
- 地址：安徽省合肥市高新區(qū)黃山路602號(hào)合肥國(guó)家大學(xué)科技園A401室
Anti -SQSTM1/p62 Rabbit pAb
價(jià)格：
在線(xiàn)咨詢(xún)
貨號(hào)：
KT012189
產(chǎn)品規(guī)格：
100 μL
Applications：
WB | IHC | IF
Species：
H,M,R | H,M
購(gòu)買(mǎi)數(shù)量：
產(chǎn)品詳情
操作說(shuō)明
注意事項(xiàng)
Product Information
|
Description |
P62 rabbit polyclonal antibody |
|
Protein full name |
Sequestosome-1 |
|
Synonyms |
SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, Sequestosome 1, NADGP, DMRV |
|
Immunogen |
Recombinant protein corresponding to Mouse P62 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Late endosome, Nucleus, PML body, Lysosome, Endoplasmic reticulum, Cytoplasm, Autophagosome, Sarcomere |
|
Predicted MW. |
48 kDa |
|
Observed MW. |
62 kDa |
|
Uniprot ID |
Q13501, O08623, Q64337 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
WB |
Human, Mouse, Rat |
1:500-1:1500 |
kidney |
|
ICC/IF |
Human, Mouse |
1:1000-1: 2000 |
HeLa, NIH/3T3 |
Background
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family . Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells.
Images
|
|
Western blot analysis of SQSTM1 p62 (GB11239-1) at dilution of 1: 500 |
|
Immunocytochemistry analysis of 4% paraformaldehyde-fixed Hela cell untreatd using p62 (GB11239-1) at dilution of 1: 1000 |
|
Immunocytochemistry analysis of 4% paraformaldehyde-fixed Hela cell with chloroquine treated using p62 (GB11239-1) at dilution of 1: 1000 |
|
Immunocytochemistry analysis of 4% paraformaldehyde-fixed NIH/3T3 cell with chloroquine treated (above) and untreatd (below) using P62 (GB11239-1) at dilution of 1: 2000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥萬(wàn)物生物科技有限公司
客服熱線(xiàn)：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區(qū)黃山路602號(hào)合肥國(guó)家大學(xué)科技園A401室